Protein folding in silico is broad in scope - starting with ab initio models and attempting to construct a mechanistic model on the basis of their predictions. This model, if sufficiently reliable, may influence the interpretation of biological processes related to protein folding. The author's computational model is expected to go beyond experimental studies, casting a new light on the complexities of biological phenomena. It acknowledges the geometric properties of the polypeptide chains as well as the influence of external force fields (particularly the aqueous environment in which the folding process takes place) and external molecules, including specific ligands.

- Introduces a unique model based on experimental observations of protein folding
- Highlights the criteria applied when comparing and assessing different approaches to the presented problem
- Explains the influence of observation-based models on the interpretation of the nature of the folding process
- Describes various ways to quantitatively assess the presented models from the viewpoint of information theory